Seattle Seahawks vs Arizona Cardinals NFL Free Pick, Odds, Preview, Prediction (9/25/25)

NFL

8:15 PM EST.

Spread: SEA -1.5 / ARI +1.5.

ML: SEA -125 / ARI +110.

Over/Under: 43.5.

Free Pick: Cardinals +1.5.

It's the Battle of the Birds in this Thursday Night Football matchup with both teams sitting at 2-1. Expect a close matchup between familiar foes. Kyler Murray loves throwing it to his TE and RBs and will be their ticket to scoring. The Seahawks have been susceptible to tight ends so far and will face their biggest test tonight against Trey McBride. They also have allowed opposing RBs to have 234 receiving yards at 11.14 YPC. This bodes well for Arizona's offensive style, and while Seattle has been great against the run so far, with Kyler's running threat, expect it to open up tonight. Expect the Cardinals to cover the spread in tonight's NFC West matchup.