New England Patriots vs Buffalo Bills NFL Free Pick, Odds, Preview, Prediction (10/5/25)

NFL

8:20 PM EST.

Spread: NE +8.5 / BUF -8.5.

ML: NE +350 / BUF -450.

Over/Under: 49.5.

Free Pick: Patriots +8.5.

AFC East division rivals face off on Sunday Night Football with the Bills as the heavy favorite. Last year, the Patriots held their own in a loss with a final score of 20-23 in the only game that featured starters from both teams. Expect the Patriots to keep it close again, as the Bills' defense ranks 31st against the run. This will allow the Patriots' run game to get going and open up their 7th-best passing attack. It will be the opposite for the Bills on offense, as the Patriots have the second-best rush defense in the league, which will cause problems for their first-ranked rushing attack. It is just too many points between familiar foes, expect the Patriots to step up against their division rival.